Proceedings of The 2nd International Conference on Applied Research in Management, Business and Economics

Year: 2019

DOI:

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Study and Construction of New Polymeric Electrodes in PVC Matrix Membrane for Amiloride Hydrochloride Drug Determination

Sarra A. Abrahem1, Suhad A. Ibrahem1* and Abdul kader SaadAbdul kader2

ABSTRACT: 

Abstract

Based on Amiloride hydrochloride-methyl orange, two electrodes of Amiloridehydrochloride were constructed in PVC matrix as ion pair complex. They were plasticized using Nitrobenzene (NB), and Di-butyl phosphate (DBP). Amiloride hydrochloride (AMH) electrodes (e1and e2) presented slopes (54.210 and 52.810 mV/decade) and linear ranges (10-5-10-2, and 2*10-5-10-2M), respectively. (e1), which is the best electrode, was based on DBP plasticizer. It gave a detection limit of 4×10-6M, slope of 54.210 mV/decade, correlation coefficient 0.9998, lifetime 36 days. The proposed electrode displayed reproducibility and good stability and was used for determining Amiloride hydrochloride in pharmaceutical samples. The interference measurements using (Na+, Cu+2, K+, Fe+3, and Mn+2) were studied for selectivity coefficient determination using the separated method, as well as the mixed metho.

Keywords: Amiloride hydrochloride, ion selective electrodes (ISE), potentiometric determination