Study and Construction of New Polymeric Electrodes in PVC Matrix Membrane for Amiloride Hydrochloride Drug Determination

April 26, 2020    0 comment


Proceedings of The 2nd International Conference on Applied Research in Management, Business and Economics

Year: 2019

DOI:

Fulltex PDF

 

Study and Construction of New Polymeric Electrodes in PVC Matrix Membrane for Amiloride Hydrochloride Drug Determination

Sarra A. Abrahem1, Suhad A. Ibrahem1* and Abdul kader SaadAbdul kader2

 

ABSTRACT: 

 

Abstract

Based on Amiloride hydrochloride-methyl orange, two electrodes of Amiloridehydrochloride were constructed in PVC matrix as ion pair complex. They were plasticized using Nitrobenzene (NB), and Di-butyl phosphate (DBP). Amiloride hydrochloride (AMH) electrodes (e1and e2) presented slopes (54.210 and 52.810 mV/decade) and linear ranges (10-5-10-2, and 2*10-5-10-2M), respectively. (e1), which is the best electrode, was based on DBP plasticizer. It gave a detection limit of 4×10-6M, slope of 54.210 mV/decade, correlation coefficient 0.9998, lifetime 36 days. The proposed electrode displayed reproducibility and good stability and was used for determining Amiloride hydrochloride in pharmaceutical samples. The interference measurements using (Na+, Cu+2, K+, Fe+3, and Mn+2) were studied for selectivity coefficient determination using the separated method, as well as the mixed metho.

Keywords: Amiloride hydrochloride, ion selective electrodes (ISE), potentiometric determination

Template 1

Sarra A. Abrahem

Department of Chemistry, College of Science, Al-Nahrain University-Iraq

Template 1

Suhad A. Ibrahem

Department of Chemistry, College of Science, Al-Nahrain University-Iraq

Template 1

Abdul kader Saad Abdul kader

Department of Physics, College of Science, Al-Mustansiriya University, Iraq

Leave a reply

Subscribe to Conference newsletter!

Sign up in the newsletter form below to receive the latest news and updates about this Conference

This Site Uses Cookies

We and our advertising partners use cookies on this site and around the web to improve your website experience and provide you with personalized advertising from this site and other advertisers. By clicking “Allow” or navigating this site, you accept the placement and use of these cookies for these purposes.